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GPX4, a downstream target of GSH action, functions as a unique intracellular antioxidant enzyme acting on membrane lipid repair, which is able to directly reduce peroxidized phospholipids produced in cell membranes (88,89), and it converts toxic lipid ROS into non-toxic lipid alcohols with the aid of GSH, which thereby reduces the level of oxidative damage to cells (90)

doi: 10.1038/s41586-019-1170-y

Without enough glutathione to neutralize the NAPQI, this toxic substance begins to build up

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Kunsch, C

40 Cinnamaldehyde is another example of a relatively simple molecule with complex reactivity